Fig. 7

HFD regulates cochlear AdipoR1, COX IV, HO-1 and G3bp1; and liver AdipoR1. Cochlear AdipoR1, cytochrome c oxidase subunit IV (COX IV) heme oxygenase-1 (HO-1; also known as heat shock protein 32, HSP 32), and a marker of stress granule (G3bp1) levels were measured in the whole cochlear lysates by Western blot analysis (a) and quantified (b–e). Cochlear AdipoR1 and HO-1 presented main effects of sex and diet while COX IV and G3bp1 displayed a main effect of diet. f Liver AdipoR1 protein levels were measured by Western blotting (a) and quantified (g). Female AdipoR1 levels were regulated by diet, but no changes were seen in male AdipoR1 in the liver. Different letters indicate significant differences between treatments. Two-way ANOVA with Tukey’s multiple comparisons test. p < 0.05. ^amain effect of sex; ^bmain effect of diet; ^cinteraction effect