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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Sex differences in hearing impairment due to diet-induced obesity in CBA/Ca mice

Fig. 5

Total adiponectin expression shows sex differences; leptin is regulated by diet but not sex. a Serum/circulating adiponectin levels were significantly higher in females compared to males (amain effect of sex, F(1, 31) = 55.00, p < 0.0001), however, there was no main effect of diet treatments (F(2, 31) = 0.5945, p = 0.5580); Two-way ANOVA, Tukey's multiple comparisons test; *p < 0.05. b Cochlear adiponectin levels were measured in the whole cochlear lysates. Dietary fat treatment increased cochlear adiponectin level only in female mice, but not in male mice. Two-way ANOVA, Fisher's LSD; amain effect of sex, F(1, 33) = 13.24, p = 0.0009; bmain effect of diet, F(2, 33) = 4.303, p = 0.0218. c Serum/circulating leptin level showed a significant increase in HFD-fed mice compared to control diet. Two-way ANOVA; Tukey's multiple comparisons test; amain effect of sex, F(1, 28) = 2.437, p = 0.1298; bmain effect of diet, F(2,28) = 17.81, p < 0.0001; *p < 0.05. d Cochlear leptin level showed no significant differences among groups. Main effect of sex, F(1, 31) = 2.249, p = 0.1438; main effect of diet, F(2,31) = 0.1752, p = 0.8401, ns not significant

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