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Fig. 7 | Biology of Sex Differences

Fig. 7

From: Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

Fig. 7

Differential acetylome across the olfactory axis in AD and PD. A Deregulated OT protein expression profile related to SIRT signaling pathway (red: up-regulation; green: down-regulation; m: men; w: women). B Western-blotting against Lys-acetylated proteins at the level of OB, OT, EC and amygdala in AD and PD women. Sample pooling (n = 5/group) was used in all biological conditions. Equal loading of the gels was assessed by stain-free digitalization. Right panels indicate relative intensity levels for multiple bands (w.1 to w.9 indicated on the blot) normalized by total protein in each gel lane across OB, OT, EC and amygdala protein extracts. C Western-blotting against Lys-acetylated proteins at the level of OB, OT, EC and amygdala in AD and PD men. Sample pooling (n = 5/group) was used in all biological conditions. Equal loading of the gels was assessed by stain-free digitalization. Right panels indicate relative intensity levels for multiple bands (m.1 to m.7 indicated on the blot) normalized by total protein in each gel lane across OB, OT, EC and amygdala protein extracts

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Biology of Sex Differences

ISSN: 2042-6410

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