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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

Fig. 2

Functional impact of the deregulated OT proteostasis in AD and PD across both sexes. A Number of common and dissimilar deregulated proteins between men and women in each neurological disorder. B Integrative analysis of our OT proteome data derived from AD subjects with the brain region-specific omics data sets from AlzData database (http://www.alzdata.org/) [34]. C Functional mapping of disrupted OT proteome in AD women and men. D Functional mapping of disrupted OT proteome in PD women and men. Black triangles indicate biological processes commonly altered in AD and PD between both sexes. E Mass spectrometry-based quantitation of astrogliosis and axonal damage markers (m: men; w: women)

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