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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Sex-divergent effects on the NAD+-dependent deacetylase sirtuin signaling across the olfactory–entorhinal–amygdaloid axis in Alzheimer’s and Parkinson’s diseases

Fig. 1

Sex differences in the OT proteome in AD and PD. A Heatmap representing the differential OT proteotyping in AD across sexes. B Sex-independent protein clusters specifically modulated in AD. C Sex-dependent protein clusters modulated in controls or in AD subjects. D Heatmap representing the differential OT proteotyping in PD across sexes. E Sex-independent protein clusters specifically modulated in PD. F Sex-dependent protein clusters modulated in controls or in PD subjects. G Circos-plot representing the OT deregulated proteome shared between AD and PD across sexes. On the inside, dark orange color represents the proteins that appear in multiple data sets and light orange color represents unique deregulated proteins specific of each experimental group. Purple lines indicate the proteome that is shared across biological conditions. H Functional clustering of proteins commonly deregulated in AD/PD men or AD/PD women. I Synaptic ontology analysis (subcellular distribution) of OT deregulated proteomes. J Synaptic ontology analysis (molecular function) of OT deregulated proteomes (m: men; w: women)

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Biology of Sex Differences

ISSN: 2042-6410

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