Fig. 2From: Integrated chromatin accessibility and DNA methylation analysis to reveal the critical epigenetic modification and regulatory mechanism in gonadal differentiation of the sequentially hermaphroditic fish, Monopterus albusDNA methylation changes in TSS region activated gene expression. A MA plots for differentially expressed genes during gonadal development. Black dots represent genes with no significantly change. Red and green dots represent significantly up-regulated and down-regulated genes during gonadal development, respectively (P < 0.05). B Gene ontology terms associated with significantly differentially expressed genes. C Different expression profile during the gonadal development. D DNA methylation level over 10-kb region centre and promoter of the differentially expressed genes from cluster 4Back to article page