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Fig. 8 | Biology of Sex Differences

Fig. 8

From: Steady-state estradiol triggers a unique innate immune response to allergen resulting in increased airway resistance

Fig. 8

Steady-state estrogen reduces airway and lung T cells, but CD19+ B cells are preserved and comparable to hormonally intact, female controls. Groups of animals were prepared as in previous figures. Bronchoalveolar lavage fluid was collected immediately following euthanasia. A–D By flow cytometry total CD3+ and CD19+, T and B cells, respectively, were determined following treatment with 5 consecutive daily i.n. OVA administration. A, C Counts of T cells and B cells per mL of returned lavage fluid and B, D counts of T and B cells acquired from remaining lung tissue are shown. E OVA-specific IgE was also measure in serum that was diluted 1:5 by ELISA. Results are representative of two separate experiments with 4–6 animals included per group. As before, statistical significance was determined using one-way ANOVA with Tukey’s post-tests. As in previous figures * indicates p < 0.05; **p < 0.01, ***p < 0.001, ****p < 0.0001

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