Table 1 Clinical and demographic data of the AS cohort
From: Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis
Variables | Total | Men | Women | p value |
|---|---|---|---|---|
n (%) | 220 (100) | 133 (60.45) | 87 (39.54) | |
Age (median [IQR]) | 72 [66–78] | 71 [65–77] | 75.5 [68–80] | 0.0008 |
Height (median [IQR]) | 163 [156–170] | 168 [163–172] | 154 [150–157.8] | < 0.0001 |
Weight (mean ± SD) | 77.11 ±14.30 | 82.18 ± 12.49 | 69.40 ± 13.47 | < 0.0001 |
Body surface (mean ± SD) | 1.81 ± 0.19 | 1.91 ± 0.15 | 1.67 ± 0.16 | < 0.0001 |
DM, n (%) | 63 (29.72) | 40 (31.25) | 23 (27.38) | 0.6452 |
HTA, n (%) | 149 (70.28) | 91 (71.09) | 58 (69.05) | 0.7607 |
Renal insufficiency, n (%) | 14 (6.60) | 8 (6.25) | 6 (7.14) | 0.7852 |
NYHA class, n (%) | ||||
I | 22 (10.78) | 17 (13.49) | 5 (6.41) | |
II | 123 (60.29) | 83 (65.87) | 40 (51.28) | |
III | 55 (26.96) | 25 (19.84) | 30 (38.46) | |
IV | 4 (1.96) | 1 (0.79) | 3 (3.85) | |
Drug medicines | ||||
ACEI, n (%) | 53 (25.24) | 32 (25.20) | 21 (25.30) | 1.000 |
ARB, n (%) | 55 (26.19) | 35 (27.60) | 20 (24.10) | 0.6320 |
Diuretics, n (%) | 116 (54.72) | 63 (49.22) | 53 (63.10) | 0.0499 |
B-blockers, n (%) | 59 (27.83) | 36 (28.13) | 23 (27.38) | 1.000 |
Statins, n (%) | 135 (63.68) | 94 (73.44) | 41 (48.81) | 0.0004 |
Biochemical analyses | ||||
BNP, pg/mL (median [IQR]) | 128 [56.5–250] | 109.5 [49.5–231.0] | 144 [67–263.5] | 0.1671 |
Triglycerides, mg/dL (median [IQR]) | 97 [76–131] | 95.5 [71.5–130.8] | 104 [83.5–131] | 0.1652 |
HDL, mg/dL (median [IQR]) | 45 [37–57] | 43 [35–53.75] | 49 [38.5–61.0] | 0.0372 |
LDL, mg/dL (mean ± SD) | 107.1 ± 34.15 | 100.1 ± 32.76 | 118.0 ± 33.58 | 0.0003 |
Echocardiographic parameters | ||||
BAV, n (%) | 69 (48.25) | 39 (49.37) | 30 (46.88) | 0.8666 |
Max gradient (median [IQR]) | 74 [65.3–88.5] | 73 [66–88] | 77 [65–89] | 0.6082 |
Mean gradient (median [IQR]) | 47 [41–57] | 47 [41–56] | 48 [41–58.5] | 0.5000 |
Valvular area echocardiography, cm2 (median [IQR]) | 0.72 [0.6–0.9] | 0.8 [0.7–0.9] | 0.7 [0.6–0.8] | 0.0024 |
End-systolic volume (cc) (median [IQR]) | 41 [25–58.5] | 45.00 [30.25–63.25] | 33 [18.5–55.0] | 0.0039 |
EF % (median [IQR]) | 67 [58–74] | 66 [57–73] | 67 [59–76.5] | 0.3813 |
Calcium score (A.U.) (median [IQR]) | 2523 [1785–5116] | 3128 [2118–5367] | 2090 [1504–3888] | 0.0471 |