Fig. 2
From: Sex-dependent expression of neutrophil gelatinase-associated lipocalin in aortic stenosis
Expression of NGAL in AVs is associated with inflammation, oxidative stress, and osteogenesis. Correlation dispersion plots for NGAL expression with inflammatory markers IL6 (A), IL8 (B), monocyte chemoattractant protein-1 CCL2 (C), RANTES (D), CD14 (E), CD44 (F), ICAM-1 (G) and Gal-3 (H); oxidative stress markers myeloperoxidase (I) and malondialdehyde (J); and osteogenic markers BMP2 (K), RUNX2 mRNA (L), Periostin mRNA (M) and calcium score evaluated by CT scan prior to the surgical valve replacement (N). Correlations were performed in stenotic AVs (n = 220). X-axis labels are referred to NGAL (pg/mL) measured in AV protein homogenates. IL, interleukin; CCL2, chemokine (C–C motif) ligand 2 (CCL2) or monocyte chemoattractant protein 1 (MCP1). CD cluster of differentiation, ICAM-1, Intercellular Adhesion Molecule 1, Gal-3, galectin-3, BMP bone morphogenetic protein, RUNX2 Runt-related transcription factor 2, POSTN periostin