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Table 4 Significantly impacted genes detected in the meta-analysis of expression data for all 7 studies integrated from the 3 major brain regions

From: Unveiling sex-based differences in Parkinson's disease: a comprehensive meta-analysis of transcriptomic studies

Direction of overexpression

Significant genes

LFC < 0

AC073283.7, ATP5J2-PTCD1, GPR4, IL15RA, ITGA5, LAMA5, MAP3K6, MEGF6, PNMT, PRDM12, RASIP1

LFC > 0

BZW1, OPTN, TMX2, UBA6

  1. Significantly impacted genes grouped by LFC value. Genes with a documented association with PD in the OpenTargets database highlighted in bold