Fig. 7

Cholesterol biosynthesis pathway gene expression is upregulated in XY mice in response to statin. A Heatmap displays relative hepatic expression levels of genes altered by sex within the cholesterol biosynthesis pathway as fold-change of statin treated compared to chow diet for each of the Four Core genotypes (N = 3 per genotype and diet). * indicates gonadal sex effect and † indicates chromosomal sex effect. * or ^†P < 0.05 by two-way ANOVA. B–E Real-time PCR quantification of representative genes from A illustrates the effects of gonadal and/or chromosomal sex on statin-induced alterations in gene expression in the cholesterol biosynthesis pathway. Two-way ANOVA with * denoting gonadal sex effect and # denoting effect due to statin treatment. * or ^#P < 0.05 and ** or ^##P < 0.01. N = 4–6. In two-way ANOVA analyses, two groups of mice were combined such that the number of mice in each group used for statistical analysis is 7–12