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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Chromosomal and gonadal sex drive sex differences in lipids and hepatic gene expression in response to hypercholesterolemia and statin treatment

Fig. 5

Gonadal and chromosomal sex regulate fatty acid metabolism. A Heatmaps display relative hepatic expression levels of genes related to fatty acid synthesis and peroxisomal beta oxidation in Apoe–/– FCG genotypes (N = 3). Expression of each genotype was relative to that in XX mice with ovaries. *P < 0.05 for gonadal or chromosomal sex by two-way ANOVA. Real-time PCR quantification of representative genes from A showing B chromosomal sex effects (Acsl1 and Acsl4), C gonadal sex effects (Scd2 and Phyh) and D both gonadal and chromosomal sex effects (Slc27a2). Two-way ANOVA with * donating gonadal sex effect and † denoting chromosomal sex effect. * or †P < 0.05 and ** or ††P < 0.01. N = 4–6. In two-way ANOVA analyses, two groups of mice were combined such that the number of mice in each group used for statistical analysis is 7–12

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