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Table 1 Sex differences in bile acid levels by comparing stage II RCC and LCC from patients aged ≥ 55 years

From: Bile acid distributions, sex-specificity, and prognosis in colorectal cancer

  

Females (RCC vs LCC)

Males (RCC vs LCC)

  

FCa

P valueb

FCa

P valueb

Primary BAs

CA

7.4

0.036

7.4

0.011

CDCA*

–

ns

6.5

0.011

Taurine-conjugated primary BAs

TCA

33.1

0.036

14.0

0.041

TCDCA

16.7

0.036

14.2

0.012

Glycine-conjugated primary BAs

GCA*

–

ns

7.8

0.020

GCDCA

14.6

0.041

10.6

0.011

Secondary BAs

DCA*

–

ns

3.4

0.011

LCA*

–

ns

1.6

0.041

UDCA*

–

ns

3.4

0.020

Taurine-conjugated secondary BAs

TDCA*

7.4

0.041

–

ns

TLCA

–

ns

–

ns

Glycine-conjugated secondary BAs

GDCA*

19.0

0.036

–

ns

GLCA

–

ns

–

ns

GUDCA*

–

ns

23.3

0.011

  1. aFC = Fold change, fold change calculated by dividing median value of right-sided colon cancer (RCC) by median value of left-sided colon cancer (LCC). bP-values estimated by the Mann–Whitney U test adjusted for false discovery rates (FDR) (Benjamini–Hochberg). ns = not significant. *Bile acids identified with sex-specific differences. CA, cholic acid; CDCA, chenodeoxycholic acid; TCA, taurocholic acid; TCDCA, taurochenodeoxycholic acid; GCA, glycocholic acid; GCDCA, glycochenodeoxycholic acid; DCA, deoxycholic acid; LCA, lithocholic acid; UDCA, ursodeoxycholic acid; TDCA, taurodeoxycholic acid; TLCA, taurolithocholic acid; GDCA, glycodeoxycholic acid; GLCA, glycolithocholic acid; GUDCA, glycoursodeoxycholic acid