Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Table 8 Interaction of allopregnanolone:progesterone ratio and sex on neural activation when viewing smoking cues (minus neutral cues)

Outcome	Log(allo/prog) by sex interaction p value	Within females: Effect of log(allo/prog) (95% CI)	p value	Within males: Effect of log(allo/prog) (95% CI)	p value	Difference in slopes (95% CI)
PCC	0.181	0.03 (− 0.07, 0.14)	0.504	− 0.05 (− 0.13, 0.03)	0.253	0.08 (− 0.03, 0.20)
ACC	0.406	− 0.01 (− 0.09, 0.08)	0.904	− 0.04 (− 0.10, 0.01)	0.133	0.04 (− 0.05, 0.13)
Lateral occipital cortex (left)	0.201	0.00 (− 0.07, 0.08)	0.900	− 0.05 (− 0.12, 0.02)	0.172	0.05 (− 0.03, 0.13)
Middle temporal gyrus (left)	0.213	0.04 (− 0.06, 0.13)	0.467	− 0.02 (− 0.09, 0.05)	0.517	0.06 (− 0.03, 0.15)

For each region of interest, the interaction effect and simple slopes by sex are depicted
PCC posterior cingulate cortex, ACC anterior cingulate cortex

ISSN: 2042-6410