Table 6 Interaction effect allopregnanolone:progesterone ratio and sex on final smoking session measures
Outcome at final smoking session | Log(allo/prog) by sex interaction p value | Within females: Effect of log(allo/prog) (95% CI) | p value | Within males: Effect of log(allo/prog) (95% CI) | p value | Difference (95% CI) between slopes |
|---|---|---|---|---|---|---|
CO (post–pre) | 0.237 | − 1.81 (− 4.12, 0.51) | 0.127 | 0.55 (− 2.15, 3.26) | 0.689 | − 2.36 (− 5.92, 1.20) |
Number of cigarettes | 0.148 | − 0.13 (− 0.42, 0.17) | 0.401 | 0.20 (− 0.20, 0.61) | 0.327 | − 0.33 (− 0.72, 0.06) |
Volume smoked (1st cigarette) | 0.803 | − 77.9 (− 222.6, 88.9) | 0.360 | − 49.5 (− 286.7, 187.7) | 0.683 | − 28.3 (− 251.0, 194.3) |
Total volume smoked | 0.256 | 193.1 (− 410.6, 796.8) | 0.531 | 548.2 (− 120.4, 1216.7) | 0.108 | − 355.0 (− 889.9, 179.8) |
NEQ1 (feel strength of nicotine) | 0.983 | 2.54 (− 3.22, 8.31) | 0.387 | 2.46 (− 3.86, 8.79) | 0.445 | 0.08 (− 7.18, 7.34) |
NEQ2 (feel “good” effects of nicotine) | 0.519 | 6.45 (− 0.71, 13.60) | 0.077 | 9.36 (1.72, 17.00) | 0.016a | − 2.91 (− 11.94, 6.12) |
NEQ3 (feel “bad” effects of nicotine) | 0.140 | − 2.99 (− 9.99, 4.01) | 0.402 | − 11.34 (− 20.50, − 2.18) | 0.015a | 8.35 (− 1.53, 18.23) |
NEQ4 (head rush) | 0.589 | − 8.62 (− 18.82, 1.57) | 0.097 | − 4.49 (− 16.22, 7.24) | 0.453 | − 4.14 (− 19.20, 10.93) |