Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Table 5 Main effects of allopregnanolone:progesterone ratio and sex on self-reported psychological measures that did not show a significant interaction effect in Table 4

Outcome	Effect of log(allo/prog)	p value	Effect of sex gender [ref: female] (95% CI)	p value
QSU-Brief	− 0.94 (− 3.19, 1.31)	0.412	− 0.38 (− 7.17, 6.40)	0.912
QSU^a	4.38 (− 5.30, 14.06)	0.375	− 17.42 (− 38.37, 3.54)	0.103
POMS: tension–anxiety	0.00 (− 0.46, 0.47)	0.987	0.44 (− 0.92, 1.80)	0.526
POMS: depression–dejection	0.11 (− 0.20, 0.42)	0.490	− 0.26 (− 1.51, 0.98)	0.681
POMS: anger–hostility	− 0.14 (− 0.65, 0.38)	0.606	− 0.29 (− 1.67, 1.08)	0.676
POMS: vigor	0.44 (− 0.32, 1.20)	0.258	2.13 (− 1.55, 5.82)	0.257

QSU-Brief Brief Questionnaire on Smoking Urges, NWSC Nicotine Withdrawal Symptom Checklist, QSU Tiffany Questionnaire of Smoking Urges, POMS Profile of Mood States
^aOnly at final scan (‘chronic’ visit); no repeated measures

ISSN: 2042-6410