Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Table 4 Interaction effect of allopregnanolone:progesterone ratio and sex on self-reported psychological measures

Outcome	Log (allo/prog) by sex interaction p value	Within females: Effect of log(allo/prog) (95% CI)	p value	Within males: Effect of log(allo/prog) (95% CI)	p value	Difference between slopes (95% CI)
QSU-Brief	0.420	− 2.05 (− 5.36, 1.26)	0.225	− 0.40 (− 2.92, 2.12)	0.756	− 1.65 (− 5.46, 2.16)
NWSC	0.047^b	− 0.98 (− 1.95, − 0.01)	0.048^b	0.13 (− 0.39, 0.67)	0.612	− 1.12 (− 2.01, − 0.22)
QSU^a	0.179	− 1.07 (− 9.16, 7.03)	0.796	8.81 (− 4.52, 22.15)	0.195	− 9.88 (− 24.29, 4.53)
POMS: tension–anxiety	0.201	− 0.38 (− 1.13, 0.38)	0.330	0.20 (− 0.29, 0.68)	0.428	− 0.57 (− 1.37, 0.22)
POMS: depression–dejection	0.937	0.09 (− 0.57, 0.75)	0.785	0.12 (− 0.12, 0.36)	0.328	− 0.03 (− 0.66, 0.61)
POMS: anger–hostility	0.118	− 0.52 (− 1.24, 0.20)	0.115	0.05 (− 0.40, 0.51)	0.815	− 0.57 (− 1.17, 0.02)
POMS: fatigue	0.034^b	− 0.50 (− 1.03, 0.02)	0.062	0.08 (− 0.37, 0.53)	0.724	− 0.58 (− 1.08, − 0.08)
POMS: vigor	0.262	1.05 (− 0.16, 2.26)	0.089	0.19 (− 0.69, 1.06)	0.675	0.87 (− 0.55, 2.28)
POMS: confusion–bewilderment	0.014^b	− 0.45 (− 0.78, − 0.12)	0.008^b	0.10 (− 0.11, 0.31)	0.352	− 0.55 (− 0.99, − 0.11)

For each outcome, the interaction effect and simple slopes by sex are depicted
QSU-Brief Brief Questionnaire on Smoking Urges, NWSC Nicotine Withdrawal Symptom Checklist, QSU Tiffany Questionnaire of Smoking Urges, POMS Profile of Mood States
^aOnly at final scan (‘chronic’ visit); no repeated measures
^bStatistical significance at level p < 0.05

ISSN: 2042-6410