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Fig. 3 | Biology of Sex Differences

Fig. 3

From: Effect of progesterone administration in male and female smokers on nicotine withdrawal and neural response to smoking cues: role of progesterone conversion to allopregnanolone

Fig. 3

Significant interaction of allopregnanolone:progesterone ratio and sex on withdrawal symptoms and mood states. A Allopregnanolone:progesterone ratio and sex significantly interacted to predict nicotine withdrawal symptoms (p = 0.047) on the Nicotine Withdrawal Symptom Checklist. The simple slope for females was significant, such that having a higher ratio of allopregnanolone:progesterone was associated with lower withdrawal symptoms (p = 0.048). B Allopregnanolone:progesterone ratio significantly interacted with sex to predict fatigue on the Profile of Moods Scale (POMS) (p = 0.034). For females, a higher ratio of allopregnanolone:progesterone was marginally associated with lower reports of fatigue (p = 0.062). C Allopregnanolone:progesterone ratio significantly interacted with sex to predict confusion on the POMS. For females, higher ratios of allopregnanolone:progesterone were associated with lower reports of confusion (p = 0.008). For details see Table 4

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