Fig. 4

Chromosome X + Y expression of gametologs in XY male placentas. There is a significant difference in male XY to female XX expression for ZFX and KDM6A (UTX) when only looking at the X chromosome CPM expression value. When we add the Y chromosome-linked CPM expression count for these genes for male samples, there is no longer a difference in expression between males XY and females XX for ZFX. KDM6A changes directionality and shows males as having significantly higher expression than females when accounting for gametolog expression. PCDH11X, when adding Y-linked CPM expression, shows a significantly higher expression than females. T test to see if there is a difference between the female CPM and the male CPM for each gene, p value < 0.05