Fig. 3

Correlation of female-to-male expression between placenta and 42 non-reproductive adult tissues. From left to right: the first column is All genes which includes 11,179 expressed genes in the placenta and contains count information in GTEx. Of the 11,179 genes 10,762 are autosomal or MT genes, and 417 are sex-linked (X or Y-linked). The second column is All genes but excluding sex-differentially (SD) genes. Exclude SD genes comprises 10,936 genes, of which, 10,580 are autosomal or MT genes, and the remaining 356 are X-linked. All SD genes includes 243 sex-differentially expressed genes in the placenta (late first trimester or term) adjusted p value < 0.05 and contains count information for GTEx tissues. Of the 243 sex-differentially expressed genes, 182 are autosomal and 61 are sex-linked (49 X-linked and 12 Y-linked). The last three columns show the coefficient correlation, r, in the log₂ female-to-male expression ratios between term placenta, late first trimester placentas, and 42 non-reproductive adult GTEx tissues when only examining the autosomal sex-differentially expressed genes (182 genes), SD and X-linked (49 genes) and SD and Y-linked (12 genes). The gold box highlights adult samples from many regions of the brain which all showed high correlation of with differential expressed sex-linked genes in the placenta. Black and bold indicates a significant correlation after correcting for multiple testing, adjusted p value < 0.05