Fig. 2

Innate immune gene expression between male XY and female XX placentas. Of the 979 innate immune genes from InnateDB, 625 genes are expressed in the late first trimester placentas and 628 are expressed in the term placentas. A MDS plot shows no clustering by genetic sex in either the late first trimester (left) or term (right) placentas. B volcano plot of the sex-differential expression for late first trimester placentas (left) and term placentas (right). Each point represents a gene. Genes that are sex differentially expressed, adjusted p value < 0.05, are indicated in purple for autosomal, orange for Y-linked, and green for X-linked