Fig. 1

Female mice exhibit higher levels of synaptosomal GluA1 and GluA2 expression in the mPFC compared to male mice. Western blotting revealed higher levels of synaptosomal GluA1 in the mPFC of females compared to males (A; n = 5–7/group). However, there are no significant differences between females and males in total levels of GluA1 (B; n = 3/group). We also found females exhibit higher levels of synaptosomal GluA2 in the mPFC compared to males (C; n = 6/group). Again, these differences are not present in total GluA2, where males and females do not exhibit significant differences (D; n = 6–7/group)