Fig. 1

Female OtmiR21Δ mice have increased lean mass by DXA/Piximus and muscle weights compared to miR21fl/fl controls. miR21 expression corrected by miR135 levels in calvaria bone (N = 8–15/group) and soleus muscles (N = 5–6/group) (A), percent lean body mass (N = 5–7/group) (B), and muscle wet weight corrected by body weight (C) of female and male OtmiR21Δ and miR21fl/fl mice (N = 12–16/group). Two-way ANOVA analyses were used to determine significant differences (Additional file 2: Table S2) *p < 0.05 compared to sex-matched miR21fl/fl controls, #p < 0.05 for overall male versus female comparisons, and £p < 0.05 compared to females of the same genotype