From: Sex differences in clinical cognitive impairment with Lewy bodies: a Chinese multicenter study
Characteristics a | All | Men | Women | t/Z/χ2 | p-value |
---|---|---|---|---|---|
n = 1038 | n = 514 | n = 524 | |||
Age at last visit, mean (SD), y | 69.89 ± 8.45 | 70.18 ± 8.26 | 69.61 ± 8.63 | − 1.26 | 0.21 |
Age at CI, mean (SD), y | 67.78 ± 8.14 | 68.17 ± 7.92 | 67.39 ± 8.34 | − 1.63 | 0.10 |
Age at PARKb, mean (SD), y | 66.78 ± 8.14 | 66.83 ± 9.04 | 66.16 ± 9.57 | − 0.13 | 0.26 |
Interval between CI and PARKb, mean (SD), y | 2.95 ± 2.56 | 2.96 ± 2.61 | 2.93 ± 2.50 | − 0.15 | 0.88 |
Education, mean (SD), y | 8.90 ± 4.54 | 10.09 ± 4.00 | 7.73 ± 4.74 | − 1.17 | 0.24 |
Course of disease, mean (SD), y | 3.05 ± 2.26 | 3.15 ± 2.40 | 2.95 ± 2.12 | − 7.50 | 0.000 |
Cardiometabolic conditionsc | |||||
Hypertension | 275 (32.54%) | 127 (31.28%) | 148 (33.71%) | 0.57 | 0.45 |
T2DM | 100 (11.83%) | 50 (12.32%) | 50 (11.39%) | 0.17 | 0.68 |
Heart disease | 116 (13.73%) | 52 (12.81%) | 64 (14.58%) | 0.56 | 0.46 |
Stroke | 109 (12.90%) | 65 (16.01%) | 44 (10.02%) | 6.73 | 0.009 |
Smokingc | 139 (16.45%) | 118 (29.06%) | 21 (4.78%) | 90.48 | 0.000 |
Alcohol consumptionc | 109 (12.90%) | 97 (23.89%) | 12 (2.73%) | 84.04 | 0.000 |
APOE ɛ4 carriersd | 56 (33.53%) | 17 (30.91%) | 39 (34.82%) | 0.25 | 0.62 |
MTA scores, mean (SD)e | |||||
Left | 1.19 ± 0.73 | 1.20 ± 0.77 | 1.18 ± 0.70 | − 0.03 | 0.98 |
Right | 1.18 ± 0.75 | 1.19 ± 0.79 | 1.18 ± 0.71 | − 0.19 | 0.85 |
Fazekas scales, mean (SD)e | 1.17 ± 0.69 | 1.16 ± 0.71 | 1.18 ± 0.68 | − 0.57 | 0.57 |
C-MMSE, mean (SD) | 17.86 ± 6.88 | 18.37 ± 7.07 | 17.36 ± 6.65 | − 2.77 | 0.006 |
MoCA, mean (SD) | 12.89 ± 6.51 | 13.44 ± 6.62 | 12.34 ± 6.35 | − 2.76 | 0.006 |
ADL, mean (SD) | 30.91 ± 12.86 | 30.47 ± 12.69 | 31.35 ± 13.02 | − 1.66 | 0.10 |
CDR, mean (SD) | 1.57 ± 0.83 | 1.53 ± 0.84 | 1.60 ± 0.83 | − 1.40 | 0.16 |
NPI scores, mean (SD)f | 12.93 ± 13.01 | 11.73 ± 12.44 | 13.93 ± 13.42 | − 1.91 | 0.05 |
Delusions | 161 (35.94%) | 71 (34.98%) | 90 (36.73%) | 0.15 | 0.67 |
Hallucinations | 336 (75.00%) | 154 (75.86%) | 182 (74.29%) | 0.15 | 0.70 |
Agitation | 117 (26.12%) | 51 (25.12%) | 66 (26.94%) | 0.19 | 0.66 |
Depression | 182 (40.63%) | 64 (31.53%) | 118 (48.15%) | 12.74 | 0.000 |
Anxiety | 161 (35.94%) | 70 (34.48%) | 91 (37.14%) | 0.34 | 0.56 |
Euphoria | 33 (7.37%) | 17 (8.37%) | 16 (6.53%) | 0.55 | 0.46 |
Apathy | 172 (38.39%) | 78 (38.42%) | 94 (38.37%) | 0.00 | 0.99 |
Disinhibition | 53 (11.83%) | 23 (11.33%) | 30 (12.24%) | 0.09 | 0.77 |
Irritability | 154 (34.38%) | 75 (36.95%) | 79 (32.24%) | 1.09 | 0.30 |
Aberrant motor behavior | 134 (29.91%) | 58 (28.57%) | 76 (31.02%) | 0.32 | 0.57 |
Night-time behavior disturbances | 321 (71.65%) | 153 (75.37%) | 168 (68.57%) | 2.53 | 0.11 |
Appetite and eating abnormalities | 112 (25.00%) | 47 (23.15%) | 65 (26.53%) | 0.68 | 0.41 |