Fig. 4

Effects of maternal reduced uteroplacental perfusion (RUPP) on offspring HOMA-IR (A), intraperitoneal glucose tolerance test (IPGTT) (B) and glucose clearance rate, as reflected by the area under IPGTT curves (C) on postnatal days 60. Male rats in the RUPP group exhibited a slower glucose clearance than male rats in the sham group. Results are expressed as mean ± SD. (n = 6). Repeated-measure ANOVA followed by Sidak’s post hoc test was used to analyze IPGTT data. In IPGTT curves (B): *p < 0.05, RUPP males vs. Sham males; ^#p < 0.05, RUPP females vs. Sham females. (b) show a significant main effect of sex. **p < 0.01