Skip to main content

Table 1 Classification of the 32 eligible studies selected for the review according to the score system

From: Sex differences in the human metabolome

First author and year Experimental design Methodology Novelty Final score Classification
N of subjects (per sex) Age stratification Analytical platform Statistical support Validation
Chekmeneva E. 2018 [65] 2 1 3 2 1 1 10 Excellent
Dunn W. B. 2014 [38] 2 2 3 2 0 1 10 Excellent
Lawton K. A. 2008 [55] 2 2 3 1 0 1 9 Excellent
Saito K. 2016 [58] 1 2 3 2 0 1 9 Excellent
Andraos S. 2021 [64] 2 2 2 1 0 1 8 Good
Caterino M. 2021 [36] 2 1 2 2 0 1 8 Good
Lau C.-H. E. 2018 [54] 2 1 3 2 0 0 8 Good
Rist M. J. 2017 [56] 2 0 3 2 0 1 8 Good
Ruoppolo M. 2015 [57] 2 1 2 2 0 1 8 Good
Trabado S. 2017 [62] 2 1 2 2 0 1 8 Good
Zaura E. 2017 [49] 2 1 2 2 0 1 8 Good
Bell J. A. 2021 [48] 2 2 1 1 0 1 7 Good
Caterino M. 2020 [35] 2 2 1 1 0 1 7 Good
De Paepe E. 2018 [66] 0 1 2 2 1 1 7 Good
Jovè M. 2016 [68] 2 0 2 2 0 1 7 Good
Liang Q. 2015 [51] 0 1 2 2 1 1 7 Good
Mittelstrass K. 2011 [24] 2 0 2 2 0 1 7 Good
Scalabre A. 2017 [59] 2 2 1 2 0 0 7 Good
Thévenot E. A. 2015 [61] 2 1 2 2 0 0 7 Good
Yu Z. 2012 [53] 2 0 2 2 0 1 7 Good
Fan S. 2018 [67] 2 0 1 2 0 1 6 Good
Gallart-Ayala H. 2018 [52] 0 1 2 1 1 1 6 Good
Li Z. 2018 [50] 2 1 2 1 0 0 6 Good
Ruoppolo M. 2014 [15] 2 1 2 1 0 0 6 Good
Slupsky C. M. 2007 [60] 2 0 1 2 0 1 6 Good
Tsoukalas D. 2019 [47] 2 2 1 1 0 0 6 Good
Vignoli A. 2018 [63] 2 1 1 2 0 0 6 Good
Das M. K. 2014 [46] 0 1 1 2 0 1 5 Fair
Hirschel J. 2020 [45] 2 0 2 1 0 0 5 Fair
Jarrell Z. R. 2020 [44] 2 0 2 1 0 0 5 Fair
Reavis Z. W. 2021 [42] 2 1 0 2 0 0 5 Fair
Takeda I. 2009 [43] 1 0 1 2 0 1 5 Fair