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Table 1 Classification of the 32 eligible studies selected for the review according to the score system

From: Sex differences in the human metabolome

First author and year

Experimental design

Methodology

Novelty

Final score

Classification

N of subjects (per sex)

Age stratification

Analytical platform

Statistical support

Validation

Chekmeneva E. 2018 [65]

2

1

3

2

1

1

10

Excellent

Dunn W. B. 2014 [38]

2

2

3

2

0

1

10

Excellent

Lawton K. A. 2008 [55]

2

2

3

1

0

1

9

Excellent

Saito K. 2016 [58]

1

2

3

2

0

1

9

Excellent

Andraos S. 2021 [64]

2

2

2

1

0

1

8

Good

Caterino M. 2021 [36]

2

1

2

2

0

1

8

Good

Lau C.-H. E. 2018 [54]

2

1

3

2

0

0

8

Good

Rist M. J. 2017 [56]

2

0

3

2

0

1

8

Good

Ruoppolo M. 2015 [57]

2

1

2

2

0

1

8

Good

Trabado S. 2017 [62]

2

1

2

2

0

1

8

Good

Zaura E. 2017 [49]

2

1

2

2

0

1

8

Good

Bell J. A. 2021 [48]

2

2

1

1

0

1

7

Good

Caterino M. 2020 [35]

2

2

1

1

0

1

7

Good

De Paepe E. 2018 [66]

0

1

2

2

1

1

7

Good

Jovè M. 2016 [68]

2

0

2

2

0

1

7

Good

Liang Q. 2015 [51]

0

1

2

2

1

1

7

Good

Mittelstrass K. 2011 [24]

2

0

2

2

0

1

7

Good

Scalabre A. 2017 [59]

2

2

1

2

0

0

7

Good

Thévenot E. A. 2015 [61]

2

1

2

2

0

0

7

Good

Yu Z. 2012 [53]

2

0

2

2

0

1

7

Good

Fan S. 2018 [67]

2

0

1

2

0

1

6

Good

Gallart-Ayala H. 2018 [52]

0

1

2

1

1

1

6

Good

Li Z. 2018 [50]

2

1

2

1

0

0

6

Good

Ruoppolo M. 2014 [15]

2

1

2

1

0

0

6

Good

Slupsky C. M. 2007 [60]

2

0

1

2

0

1

6

Good

Tsoukalas D. 2019 [47]

2

2

1

1

0

0

6

Good

Vignoli A. 2018 [63]

2

1

1

2

0

0

6

Good

Das M. K. 2014 [46]

0

1

1

2

0

1

5

Fair

Hirschel J. 2020 [45]

2

0

2

1

0

0

5

Fair

Jarrell Z. R. 2020 [44]

2

0

2

1

0

0

5

Fair

Reavis Z. W. 2021 [42]

2

1

0

2

0

0

5

Fair

Takeda I. 2009 [43]

1

0

1

2

0

1

5

Fair