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Table 2 Sex-specific hazard ratios (HRs) and 95%CIs between cardiovascular disease (CVD) events and dementia subtypes: a prospective analysis

From: Sex differences in the association between cardiovascular diseases and dementia subtypes: a prospective analysis of 464,616 UK Biobank participants

Dementia

Sex

Did not experience any CVD event

Experienced any CVD

Only experienced CHD

Only experienced stroke

Only experienced heart failure

All-cause dementia

All participants

Reference

2.20 (2.06, 2.35)

1.69 (1.53, 1.86)

2.37 (2.05, 2.75)

2.19 (1.95, 2.46)

Female

Reference

2.31 (2.07, 2.57)

1.84 (1.55, 2.18)

2.40 (1.91, 3.02)

2.10 (1.73, 2.54)

Male

Reference

2.01 (1.85, 2.18)

1.52 (1.35, 1.71)

2.24 (1.86, 2.71)

2.14 (1.85, 2.47)

Ratio of HR (female/male)

 

1.20 (1.13, 1.28)

1.28 (1.15, 1.42)

1.12 (0.97, 1.31)

1.00 (0.89, 1.13)

Alzheimer's disease

All participants

Reference

1.71 (1.53, 1.90)

1.50 (1.28, 1.75)

1.48 (1.12, 1.95)

1.57 (1.28, 1.92)

Female

Reference

2.07 (1.75, 2.45)

1.92 (1.50, 2.46)

1.44 (0.93, 2.23)

1.76 (1.30, 2.40)

Male

Reference

1.46 (1.26, 1.68)

1.25 (1.03, 1.53)

1.44 (1.00, 2.06)

1.39 (1.05, 1.82)

Ratio of HR (female/male)

 

1.50 (1.34, 1.67)

1.63 (1.39, 1.91)

1.06 (0.80, 1.41)

1.32 (1.07, 1.62)

Vascular dementia

All participants

Reference

3.37 (2.98, 3.82)

2.01 (1.66, 2.45)

5.01 (4.00, 6.27)

2.99 (2.41, 3.72)

Female

Reference

2.77 (2.21, 3.47)

1.94 (1.34, 2.79)

4.13 (2.78, 6.14)

2.27 (1.52, 3.41)

Male

Reference

3.35 (2.87, 3.91)

1.89 (1.50, 2.38)

5.24 (3.98, 6.91)

3.22 (2.49, 4.16)

Ratio of HR (Female/Male)

 

0.86 (0.75, 0.98)

1.05 (0.84, 1.30)

0.82 (0.64, 1.04)

0.73 (0.57, 0.93)

  1. All HRs were adjusted for age at baseline, race/ethnicity, educational years, income level, physical activity level, leisure activities, body mass index (BMI), smoking status, diabetes status, hypertension status, and APOE