Table 1 Characteristics of participants by sex, CVD and dementia experienced or not, n (%)
Characteristics | N | CVD experienced or not | Dementia experienced or not | ||||||
|---|---|---|---|---|---|---|---|---|---|
|  |  | Female (n = 251,039) | Male (n = 213,577) | Female (n = 251 039) | Male (n = 213,577) | ||||
|  |  | No (n = 239,138) | Yes (n = 11,901) | No (n = 189,827) | Yes (n = 23,750) | No (n = 248,461) | Yes (n = 2578) | No (n = 210,628) | Yes (n = 2949) |
Race/ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 White | 440,922 | 227,070 (51.5) | 11,267 (2.6) | 179,911 (40.8) | 22,674 (5.1) | 235,855 (53.5) | 2482 (0.6) | 199,760 (45.3) | 2825 (0.6) |
 Non-White | 23,694 | 12,068 (50.9) | 634 (2.7) | 9916 (41.9) | 1076 (4.5) | 12,606 (53.2) | 96 (0.4) | 10,868 (45.9) | 124 (0.5) |
Education level (years) | Â | Â | Â | Â | Â | Â | Â | ||
 <  = 10 | 228,838 | 115,524 (50.5) | 7674 (3.4) | 91,069 (39.8) | 14,571 (6.4) | 121,590 (53.1) | 1608 (0.7) | 103,844 (45.4) | 1796 (0.8) |
 11–12 | 55,721 | 30,873 (55.4) | 1170 (2.1) | 21,461 (38.5) | 2217 (4) | 31,763 (57.0) | 280 (0.5) | 23,394 (42) | 284 (0.5) |
 > 12 | 180,057 | 92,741 (51.5) | 3057 (1.7) | 77,297 (42.9) | 6962 (3.9) | 95,108 (52.8) | 690 (0.4) | 83,390 (46.3) | 869 (0.5) |
Physical activity level (MET) | Â | Â | Â | Â | Â | Â | Â | ||
 Light (< 600) | 105,714 | 55,336 (52.4) | 3395 (3.2) | 40,892 (38.7) | 6091 (5.8) | 58,142 (55) | 589 (0.6) | 46,295 (43.8) | 688 (0.7) |
 Moderate (600–3000) | 186,389 | 99,987 (53.6) | 4710 (2.5) | 72,402 (38.8) | 9290 (5) | 103,610 (55.6) | 1087 (0.6) | 80,512 (43.2) | 1180 (0.6) |
 High (≥ 3000) | 172,513 | 83,815 (48.6) | 3796 (2.2) | 76,533 (44.4) | 8369 (4.9) | 86,709 (50.3) | 902 (0.5) | 83,821 (48.6) | 1081 (0.6) |
Income level (ÂŁ) | Â | Â | Â | Â | Â | Â | Â | Â | |
 Less than 18,000 | 104,445 | 57,177 (54.7) | 4994 (4.8) | 34,189 (32.7) | 8085 (7.7) | 61,014 (58.4) | 1157 (1.1) | 41,134 (39.4) | 1140 (1.1) |
 18,000 to 30,999 | 113,933 | 60,359 (53) | 3156 (2.8) | 43,862 (38.5) | 6556 (5.8) | 62,825 (55.1) | 690 (0.6) | 49,542 (43.5) | 876 (0.8) |
 31,000 to 51,999 | 120,669 | 61,580 (51) | 2044 (1.7) | 52,124 (43.2) | 4921 (4.1) | 63,212 (52.4) | 412 (0.3) | 56,514 (46.8) | 531 (0.4) |
 Greater than 52,000 | 125,569 | 60,022 (47.8) | 1707 (1.4) | 59,652 (47.5) | 4188 (3.3) | 61,410 (48.9) | 319 (0.3) | 63,438 (50.5) | 402 (0.3) |
No. of leisure activities | Â | Â | Â | Â | Â | Â | Â | ||
 No | 131,434 | 67,325 (51.2) | 3877 (3) | 52,972 (40.3) | 7260 (5.5) | 70,384 (53.6) | 818 (0.6) | 59,303 (45.1) | 929 (0.7) |
 One | 202,587 | 101,469 (50.1) | 4987 (2.5) | 85,320 (42.1) | 10,811 (5.3) | 105,303 (52) | 1153 (0.6) | 94,739 (46.8) | 1392 (0.7) |
 Two or more | 130,595 | 70,344 (53.9) | 3037 (2.3) | 51,535 (39.5) | 5679 (4.4) | 72,774 (55.7) | 607 (0.5) | 56,586 (43.3) | 628 (0.5) |
Body mass index (kg/m2) | Â | Â | Â | Â | Â | Â | Â | ||
 Underweight < 18.5 | 2398 | 1847 (77.0) | 68 (2.8) | 445 (18.6) | 38 (1.6) | 1887 (78.7) | 28 (1.2) | 470 (19.6) | 13 (0.5) |
 Normal [18.5,25.0) | 153,058 | 96,724 (63.2) | 2739 (1.8) | 49,653 (32.4) | 3942 (2.6) | 98,551 (64.4) | 912 (0.6) | 52,847 (34.5) | 748 (0.5) |
 Overweight [25.0,30.0) | 198,230 | 87,839 (44.3) | 4369 (2.2) | 95,114 (48) | 10,908 (5.5) | 91,227 (46) | 981 (0.5) | 104,683 (52.8) | 1339 (0.7) |
 Obese >  = 30 | 110,930 | 52,728 (47.5) | 4725 (4.3) | 44,615 (40.2) | 8862 (8) | 56,796 (51.2) | 657 (0.6) | 52,628 (47.4) | 849 (0.8) |
Smoking status | Â | Â | Â | Â | Â | Â | Â | Â | |
 Never | 254,650 | 143,769 (56.5) | 5821 (2.3) | 96,819 (38) | 8241 (3.2) | 148,187 (58.2) | 1403 (0.6) | 103,917 (40.8) | 1143 (0.5) |
 Past | 162,083 | 74,956 (46.3) | 4582 (2.8) | 70,301 (43.4) | 12,244 (7.6) | 78,601 (48.5) | 937 (0.6) | 81,077 (50) | 1468 (0.9) |
 Current | 47,883 | 20,413 (42.6) | 1498 (3.1) | 22,707 (47.4) | 3265 (6.8) | 21,673 (45.3) | 238 (0.5) | 25,634 (53.5) | 338 (0.7) |
Diabetes status | Â | Â | Â | Â | Â | Â | Â | Â | |
 No | 440,477 | 231,924 (52.7) | 10,368 (2.4) | 178,735 (40.6) | 19,450 (4.4) | 239,963 (54.5) | 2329 (0.5) | 195,749 (44.4) | 2436 (0.6) |
 Yes | 24,139 | 7214 (29.9) | 1533 (6.4) | 11,092 (46) | 4300 (17.8) | 8498 (35.2) | 249 (1) | 14,879 (61.6) | 513 (2.1) |
Hypertension status | Â | Â | Â | Â | Â | Â | Â | Â | |
 No | 336,017 | 183,668 (54.7) | 4749 (1.4) | 136,517 (40.6) | 11,083 (3.3) | 186,945 (55.6) | 1472 (0.4) | 145,983 (43.5) | 1617 (0.5) |
 Yes | 128,599 | 55,470 (43.1) | 7152 (5.6) | 53,310 (41.5) | 12,667 (9.9) | 61,516 (47.8) | 1106 (0.9) | 64,645 (50.3) | 1332 (1) |
APOE | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 No apoE4 | 112,993 | 56,186 (49.7) | 3135 (2.8) | 47,608 (42.1) | 6064 (5.4) | 58,874 (52.1) | 447 (0.4) | 53,030 (46.9) | 642 (0.6) |
 One apoE4 | 342,293 | 178,142 (52) | 8535 (2.5) | 138,430 (40.4) | 17,186 (5) | 184,815 (54) | 1862 (0.5) | 153,568 (44.9) | 2048 (0.6) |
 Two apoE4 | 9330 | 4810 (51.6) | 231 (2.5) | 3789 (40.6) | 500 (5.4) | 4772 (51.2) | 269 (2.9) | 4030 (43.2) | 259 (2.8) |