Fig. 2
Sex differences in transcriptomic profiles of aging murine urinary bladders. Venn diagrams showing age and sex associated overlaps and intersecting transcriptomic profiles of significantly differentially upregulated genes in aged mice compared to 3-month-old mice within A females B males, and between C age-matched males and females. Examples of genes associated with B cells are indicated by arrows. Total RNA from healthy male and female urinary bladders was subjected to bulk-RNA sequencing. Differential expression was assessed using DESeq2 program in R (1.4.0) with a Padj < 0.05 (FDR) and a log2fold change cut off of 0.58. Venn diagrams were generated from resulting gene lists using the VennDiagram (1.6.2) package in R