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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Treatment of male and female spontaneously hypertensive rats with TNF-α inhibitor etanercept increases markers of renal injury independent of an effect on blood pressure

Fig. 2

Quantification of TNF-α signaling and inflammatory cytokines in whole kidney homogenates of SHR. Rats were euthanized at 16 weeks of age following a 31-day treatment regimen of either vehicle (n=6/group) or increasing doses of etanercept (n=6/group). Kidneys were snap-frozen and homogenized for biochemical analysis of renal TNF-α (panel A), renal phosphorylation of NFκB (panel B), excretion of MCP-1 (panel C), renal TACE (panel D), and renal TGF-β (panel E). Data were compared using a two-way ANOVA. Values are mean ± SEM

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Biology of Sex Differences

ISSN: 2042-6410

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