Susceptibility of female rats to cardiac arrhythmias following refeeding after severe food restriction

Table 3 Effect of refeeding after severe food restriction on heart function

Parameter	Timepoint	F-CT	M-CT	F-sFR-Refed	M-sFR-Refed
PP mmHg	Baseline	142 ± 18	54.9 ± 6.3*	131 ± 6.1	52.3 ± 2.3*
	5 min	143 ± 12	56.8 ± 9.4*	151 ± 13	62.9 ± 6.5*
	60 min	197 ± 10	69.6 ± 15*	199 ± 11	96.8 ± 16*
LVEDP mmHg	Baseline	12 ± 1.5	12 ± 2.3	14 ± 1.5	11 ± 1.2
	5 min	78 ± 5.5	10 ± 2.0*	84 ± 11	19 ± 4.7*
	60 min	72 ± 6.8	12 ± 2.2*	67 ± 12	33 ± 11
dLVP mmHg	Baseline	140 ± 9.9	101 ± 12	141 ± 14	114 ± 18
	5 min	34.8 ± 10	81.2 ± 26*	26.8 ± 7.4	87.5 ± 15*
	60 min	76.3 ± 7.2	75.8 ± 26	75.3 ± 7.2	101 ± 26
Max dP/dt mmHg/s	Baseline	3083 ± 199	2098 ± 283*	3014 ± 289	2366 ± 352
	5 min	619.2 ± 217	1462 ± 421	418.8 ± 129	1819 ± 278*
	60 min	1837 ± 150	1699 ± 576	1724 ± 135	1991 ± 522
Min dP/dt mmHg/s (n)	Baseline	− 1768 ± 145	− 1178 ± 185*	− 1614 ± 152	− 1292 ± 244
	5 min	− 303.0 ± 83.4	− 703.5 ± 230	− 232.3 ± 61.5	− 757.2 ± 121*
	60 min	− 1017 ± 92.1	− 880.1 ± 326	− 970.8 ± 70.2	− 1122 ± 317
HR bpm	Baseline	178 ± 8.8	144 ± 19	145 ± 18	153 ± 5.8
	5 min	149 ± 14	140 ± 16	102 ± 18	163 ± 15*
	60 min	178 ± 5.9	143 ± 13*	141 ± 16	143 ± 7.2

Perfusion pressure (PP), left ventricle end diastolic pressure (LVEDP), developed left-ventricular pressure (dLVP), maximum and minimum left ventricular pressure (dP/dt) and heart rate (HR) in male (M, n = 5/group) and female (F, n = 7/group) rats maintained on a normal diet for the duration of the study (CT) or for 3 months after a 2-week severe food restricted period (sFR-Refed). Values are expressed as the mean ± SEM; n, group size; *p < 0.05 vs. F, same diet by unpaired Student’s t test

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