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Fig. 4 | Biology of Sex Differences

Fig. 4

From: Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers

Fig. 4

HDAC activity is greater in the newborn female DG and the degree of inhibition of HDAC activity by TSA is greater in females.  A Enzymes important for histone acetylation and deacetylation. B At PN0, expression of Class I, Class IIa and IIb HDACs quantified by qPCR did not differ by sex in the DG. C On PN1 HDAC activity was greater in the female DG (**p < 0.01). D In a separate cohort of animals, the sex difference in HDAC activity was confirmed (**p < 0.01, compared to vehicle treated males). While TSA significantly reduced HDAC activity in the DG of both sexes, there was a more robust decrease in HDAC activity within the female DG (*p < 0.05, effect of TSA treatment in males; ***p < 0.001, effect of TSA treatment in females). E TSA induced a greater percentage of inhibition of HDAC activity in the DG of females compared to males (**p < 0.01)

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