Fig. 4From: Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiersHDAC activity is greater in the newborn female DG and the degree of inhibition of HDAC activity by TSA is greater in females. A Enzymes important for histone acetylation and deacetylation. B At PN0, expression of Class I, Class IIa and IIb HDACs quantified by qPCR did not differ by sex in the DG. C On PN1 HDAC activity was greater in the female DG (**p < 0.01). D In a separate cohort of animals, the sex difference in HDAC activity was confirmed (**p < 0.01, compared to vehicle treated males). While TSA significantly reduced HDAC activity in the DG of both sexes, there was a more robust decrease in HDAC activity within the female DG (*p < 0.05, effect of TSA treatment in males; ***p < 0.001, effect of TSA treatment in females). E TSA induced a greater percentage of inhibition of HDAC activity in the DG of females compared to males (**p < 0.01)Back to article page