Fig. 2

Newborn male DG expresses less of the demethylating enzyme, Gadd45α.  A Enzymes important for DNA methylation and demethylation. B Male and female DNMT activity was not significantly different in the DG at PN1. C Within the DG, expression of the de novo DNA methyltransferase enzymes, DNMT3a and DNMT3b did not differ at PN0. Females expressed more DNMT1 than males on PN0 in this brain region (*p < 0.05, compared to males). D Females expressed significantly more Gadd45α in the DG on PN1, but expression of Gadd45β did not differ between the sexes (*p < 0.05). E At PN0, males and females expressed similar amounts of the demethylating family of TET enzymes