Fig. 1
From: Neurogenesis in the neonatal rat hippocampus is regulated by sexually dimorphic epigenetic modifiers
DNMT inhibitor Zebularine decreases proliferation and DNA methylation in the DG of newborn male rats, but not female rats. A Administration of ZEB on PN0 and PN1 interacted with sex to affect proliferation in the DG, such that males generated more new cells than females and ZEB decreased proliferation in the DG, but did not further reduce proliferation in the female DG (*p < 0.05, compared to vehicle-treated males). B On PN1, DNA in the DG of males is nearly twice as methylated as DNA in the female DG (*p < 0.05). C More DNA was methylated in the DG of males compared to females and ZEB significantly reduced DNA methylation in the DG of males but caused no further reduction in females (*p < 0.05, compared to vehicle-treated males)