Fig. 5

The effects of sex, MetS, and exercise training (ET) on cardiomyocyte cross-sectional area and left ventricular collagen content at 10 months of age in sedentary and exercise-trained male and female standard diet-fed wild-type (SD/WT) and high-fat diet-fed APOB-100 transgenic (HFD/APOB-100) mice. A Representative hematoxylin–eosin (HE, ×40 and ×100) and B picrosirius red/fast green-stained (PSFG, ×10) sections, C Cardiomyocyte cross-sectional area, and D Left ventricular collagen content. Values are mean ± SEM, n = 6/group, ^$p < 0.05, female vs. male groups, *p < 0.05, HFD/APOB-100 vs. SD/WT groups, ^#p < 0.05, ET vs. sedentary groups; Three-Way ANOVA (Holm-Sidak post hoc test). The black lines on the representative images mean 50 μm (Panels A and B)