Fig. 1

Analysis of circulating parameters in COVID-19 patients with moderate/severe and mild/no ARDS. Lymphocyte and neutrophil number, D-Dimer, ferritin, E2, testosterone, soluble ACE2 and Ang1-7 plasma levels were measured in total (A), female (B) and male (C) patients at time of admission to hospital. Patients were divided according to ARDS occurrence at time of admission (P/F < 200 mmHg indicating moderate/severe ARDS and P/F  ≥ 200 mmHg, indicating mild/no ARDS). Data referred to parameters are reported as mean ± standard deviation (SD). Data were analyzed using Mann–Whitney U test. *P < 0.05 was considered statistically significant