Fig. 4

PPI network and Cox regression analysis of immune-related DEGs. A, B PPI networks of the immune-related DEGs plotted by Cytoscape in female and male patients with LUAD. C, D Top 30 genes with most number of adjacent nodes in female and male patients with LUAD. E, F Univariate Cox analysis of the immune-related DEGs in female and male patients with LUAD, and genes with p < 0.05 displayed in forest plots. G, H Two-way Venn diagram comparing the key genes in female and male groups. CCR2, LCP2, and PTPRC were selected as prognostic factors of female patients with LUAD. BTK and CCR2 were screened as prognostic factors of male patients with LUAD. A p < 0.05 was considered to be statistically significant