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Table 5 Bioinformatic analyses of miRNAs altered in maternal serum or correlating with hPL in FGR pregnancies

From: Sexually dimorphic patterns in maternal circulating microRNAs in pregnancies complicated by fetal growth restriction

miRNA ID

FGR altered

miRNA

(QPCR data)

Sexual dimorphism

(Current dataset)

Correlation with biochemical marker of placental dysfunction (hPL)

Selected gene targets

Evidence level:

-Strong (bold)

-Weak (unbolded)

-Predicted (italics)

miR-28-5p

MIMAT0000085

Yes

↓in FGR females (QPCR)

No

CDKN1A, MAPK1, IGFI, RAP1B, MAD2L1, SLC7A5, CCND3

PAPPA, CASP3

miR-29c-3p

MIMAT0000681

No

↑ males in microarray

 + ve correlation [hPL] males

Yes

R2 = 0.467

p < 0.05

CDK6, BCL2, MMP2, PTEN, AKT3, LAMC1, LAMC2, DNMT3A, COL1A, COL3A, FBA, FBB, FBG, PDGFRB

VEGFA

miR-301a-3p

MIMAT0000688

Yes

↓ in FGR males (QPCR)

No

BCL2L11, PAI-1, RUNX3, PTEN, NKRF, TGFβR2, DNMT1, ESR1, XIAP, IGF2R, PUMA, SLC6A6, IGF1, PPARG

miR-454-3p

MIMAT0003885

Yes

 + ve correlation [hPL] females

Yes

R2 = 0.511

p < 0.01

SMAD4, TGFβR2, ALK7, CXCL12, TP53, IGF2R, CCND2, MAPK1, XIAP, PARP1, SLC38A2, SLC6A6, IGF1, PPARG, DICER1, H19

  1. Potentially relevant gene targets selected from literature-based databases. Bold = experimentally validated as a target using STRONG methods (reporter assay, Western blot, qPCR); unbold = experimentally validated as a target using WEAK methods (microarray, NGS, pSILAC, other); italics = predicted target but not experimentally validated. FGR fetal growth restriction, hPL human placental lactogen. Correlations analysed using Spearman test