Table 3 MicroRNAs differentially expressed in maternal serum between FGR and uncomplicated pregnancies identified by microarray
miRNA ID | SD | ddCq adverse/normal | Fold-change | Unadjusted p value | Sexual dimorphism | Reported association with pregnancy pathology |
|---|---|---|---|---|---|---|
miR-28-5p MIMAT0000085 | 0.641 | − 1.258 | − 2.4 | 0.029 | ↑ F non-pregnant plasma [39] | Not reported |
miR-200b-3p MIMAT0000318 | 0.169 | − 0.874 | − 1.8 | 0.012 | ↑ M cerebellum + colorectal mucosa [40] | ↑ Placental expression in PE with SGA [41] ↑ Myometrial expression in mouse model of PTB [42] |
miR-224-5p MIMAT0000281 | 0.426 | − 0.931 | − 1.9 | 0.022 | Not reported | ↑ Placental expression and maternal serum levels in PE [43] ↑ In trophoblasts exposed to hypoxia [44] |
miR-378a-3p MIMAT0000732 | 0.275 | − 0.491 | − 1.4 | 0.038 | ↑ F normal-term placenta [45] | ↑ Placental expression in PTB [46] ↓ Expression in EPL decidua [47] |
miR-526b-5p MIMAT0002835 | 0.420 | − 1.463 | − 2.8 | 0.026 | ↑ M cerebellum [40] | Placental specific C19MC cluster |
miR-550a-3p MIMAT0003257 | 0.254 | − 0.429 | − 1.3 | 0.043 | Not reported | Not reported |
miR-29c-3p MIMAT0000681 | 0.089 | 0.332 |  + 1.3 | 0.0051 | ↑ M plasma [39] ↑ F cerebellum [40] | ↑ Plasma levels in gestationally obese women [51] |
miR-301a-3p MIMAT0000688 | 0.364 | 0.588 |  + 1.5 | 0.048 | ↑ M peripheral blood [40] | ↑ Maternal serum levels in PE [43] |
miR-409-3p MIMAT0001639 | 0.422 | 1.716 |  + 3.3 | 0.02 | Plasma concentration + vely correlates with lung function in asthmatic boys [52] | High placental expression (C14MC cluster) ↓ Maternal serum levels in PE [53] |
miR-454-3p MIMAT0003885 | 0.727 | 1.396 |  + 2.6 | 0.031 | ↑ M peripheral blood [40] ↑ M FGR fetal heart baboon [54] | ↑ Placental expression in PE [55] |
miR-551a MIMAT0003214 | 0.303 | 0.988 |  + 2.0 | 0.03 | Not reported | Not reported |