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Table 1 Sex differences in PAG ECS proteome

From: Sex differences in the expression of the endocannabinoid system within V1M cortex and PAG of Sprague Dawley rats

 

Accession

Max fold change over other sex

Anova (p)

Detected greater in female

ABHD6_MOUSE*

1.51

0.03

MGLL_MOUSE*

1.44

0.01

NAPEP_MOUSE

1.34

0.93

PLD3A_MOUSE

1.11

0.46

PLD2_MOUSE

1.18

0.56

DGLB_MOUSE

1.05

0.56

DGLA_RAT;DGLA_MOUSE

1.01

0.85

Detected greater in male

PHLD_MOUSE

1.52

0.15

PLD1_RAT;PLD1_MOUSE

1.18

0.30

PLD3_MOUSE

1.07

0.40

PLD6_MOUSE

1.15

0.84

CNR1_RAT

2.49

0.13

CNRP1_MOUSE;CNRP1_RAT

1.02

0.82

ABD12_MOUSE

1.02

0.79

  1. Summary of endocannabinoid system (ECS) enzymes detected in greater quantity in either female or male PAG samples, as measured by quantitative proteomics. The 2-AG hydrolyzing enzymes MAGL and ABHD6 (bold) were detected at significantly higher fold-detection for females vs males (*ABHD6 female vs. male p = 0.03, MAGL female vs. male p = 0.01). Italics indicate study via IHC. CNR2 and FAAH were below the level of detection in this study.
  2. Protein gene abbreviations: ABHD6 alpha/beta-hydrolase domain containing 6; MGLL monoacylglycerol lipase; NAPEP N-acyl-phosphatidylethanolamine-specific phospholipase D; PLD3A phospholipase D3A; PLD2 phospholipase D2; DGLB diacylglycerol lipase beta; DGLA diacylglycerol lipase alpha; PHLD phosphatidylinositol-glycan-specific phospholipase D; PLD1 phospholipase D1; PLD3 phospholipase D3; PLD6 phospholipase D6; CNR1 cannabinoid receptor 1; CNRP1 cannabinoid receptor interacting protein 1; ABD12 alpha/beta-hydrolase domain containing 12