Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Table 3 Echocardiographic parameters in males 16 weeks after induction of Ampkα2 deletion by tamoxifen injection

Echocardiographic parameters	Ampkα2^f/f n = 7	Ampkα2ciKO n = 7
HR (beats/min)	519 ± 42	533 ± 47
IVSd (mm)	0.781 ± 0,158	0.831 ± 0.148
IVSs (mm)	1.276 ± 0.191	1.330 ± 0.191
LVIDd (mm)	3.84 ± 0.30	4.13 ± 0.38
LVIDs (mm)	2.26 ± 0.28	2.67 ± 0.49*
LVPWd (mm)	0.738 ± 0.219	0.741 ± 0.192
LVPWs (mm)	1.286 ± 0.153	1.196 ± 0.181
EDV (ml)	0.14 ± 0.03	0.18 ± 0.05*
ESV (ml)	0.03 ± 0.01	0.06 ± 0.04*
EF (%)	78.3 ± 4.53	71.1 ± 8.61*
SV (ml)	0.11 ± 0.02	0.12 ± 0.02
FS (%)	41.32 ± 4.10	35.62 ± 6.48*
CO (ml/min)	58.3 ± 12.5	65.9 ± 11.7

Statistical differences are highlighted in bold
HR, heart rate; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVWPd, left ventricular posterior wall thickness at end-diastole; LVWPs, left ventricular posterior wall thickness at end-systole; EDV, end-diastolic volume; ESV, end-systolic volume; EF, left ventricular ejection fraction; SV, stroke volume; FS, left ventricular fractional shortening; CO, cardiac output; *p < 0.05 Ampkα2^f/f vs Ampkα2ciKO

ISSN: 2042-6410