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Table 3 Echocardiographic parameters in males 16 weeks after induction of Ampkα2 deletion by tamoxifen injection

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Echocardiographic parameters Ampkα2f/f n = 7 Ampkα2ciKO n = 7
HR (beats/min) 519 ± 42 533 ± 47
IVSd (mm) 0.781 ± 0,158 0.831 ± 0.148
IVSs (mm) 1.276 ± 0.191 1.330 ± 0.191
LVIDd (mm) 3.84 ± 0.30 4.13 ± 0.38
LVIDs (mm) 2.26 ± 0.28 2.67 ± 0.49*
LVPWd (mm) 0.738 ± 0.219 0.741 ± 0.192
LVPWs (mm) 1.286 ± 0.153 1.196 ± 0.181
EDV (ml) 0.14 ± 0.03 0.18 ± 0.05*
ESV (ml) 0.03 ± 0.01 0.06 ± 0.04*
EF (%) 78.3 ± 4.53 71.1 ± 8.61*
SV (ml) 0.11 ± 0.02 0.12 ± 0.02
FS (%) 41.32 ± 4.10 35.62 ± 6.48*
CO (ml/min) 58.3 ± 12.5 65.9 ± 11.7
  1. Statistical differences are highlighted in bold
  2. HR, heart rate; IVSd, interventricular septal thickness at end-diastole; IVSs, interventricular septal thickness at end-systole; LVIDd, left ventricular internal dimension at end-diastole; LVIDs, left ventricular internal dimension at end-systole; LVWPd, left ventricular posterior wall thickness at end-diastole; LVWPs, left ventricular posterior wall thickness at end-systole; EDV, end-diastolic volume; ESV, end-systolic volume; EF, left ventricular ejection fraction; SV, stroke volume; FS, left ventricular fractional shortening; CO, cardiac output; *p < 0.05 Ampkα2f/f vs Ampkα2ciKO