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Fig. 9 | Biology of Sex Differences

Fig. 9

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 9

Cardiolipin profile and oxidative capacities 16 weeks after cardiac-specific Ampkα2 deletion in control (Sham) and ovariectomized (OVX) female mice. A Total cardiolipin content. B Relative content of major cardiolipin species. C Relative content of minor cardiolipin species. D Expression of genes related to cardiolipin biosynthesis and maturation: acyl-CoA synthetase long-chain family member 1 (Acsl1), CDP-diacylglycerol synthase 1 (Cds1), cardiolipin synthase 1 (Crls1), tafazzin (Taz), elongation of very long chain fatty acids-like 2 (Elovl2), elongation of long chain fatty acids (Elovl5), fatty acid desaturase 1 (Fads1) and fatty acid desaturase 2 (Fads2). E Rate of respiration after successive addition of pyruvate (1 mM), glutamate (10 mM), succinate (15 mM), amytal (1 mM). (n = 4 to 7 per experimental group). ANOVA: #p ≤ 0.05 for the OVX effect; §p < 0.05 for the genotype effect, $p < 0.05 interaction. Post hoc Tukey test: *p < 0.05, **p < 0.01 CT-OVX vs KO-OVX

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Biology of Sex Differences

ISSN: 2042-6410

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