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Fig. 8 | Biology of Sex Differences

Fig. 8

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 8

Cardiac function and myocardial fibrosis in control (Sham) and ovariectomized (OVX) female mice 16 weeks after cardiac-specific Ampkα2 deletion. A Uterus weight. B Heart weight. C brain natriuretic peptide (Bnp) gene expression in left ventricle. D Left ventricular ejection fraction. E Left ventricular fractional shortening. F Left ventricular internal dimension at end-systolic (LVIDs). G Left ventricular internal dimension at end-diastolic (LVIDd). H Representative pictures of fibrosis analysis by Sirius red staining of subequatorial heart section. I Percentage of total fibrosis. ANOVA: # p < 0.05, ### p < 0.001 for the OVX effect; §§p < 0.01 for the genotype effect, $$p < 0.01 interaction. Post hoc Tukey test: *p < 0.05, **p < 0.01 Sham vs OVX

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Biology of Sex Differences

ISSN: 2042-6410

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