Fig. 6From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males onlyLeft ventricular cardiolipin profile in male and female mice 16 weeks after cardiac-specific Ampkα2 deletion. A Total cardiolipin content in male mice. B Total cardiolipin content in female mice. C Relative content of each identified cardiolipin species in male mice. D Relative content of each identified cardiolipin species in female mice. E Expression of genes related to cardiolipin biosynthesis and maturation: acyl-CoA synthetase long-chain family member 1 (Acsl1), CDP-diacylglycerol synthase 1 (Cds1), cardiolipin synthase 1 (Crls1), tafazzin (Taz), elongation of very long chain fatty acids-like 2 (Elovl2), elongation of long chain fatty acids (Elovl5), fatty acid desaturase 1 (Fads1) and fatty acid desaturase 2 (Fads2). ANOVA: µ p < 0.05, µµ p ≤ 0.01 for the sex effect; $p < 0.05, $$p < 0.01 for interaction; Post hoc Tukey test: * p < 0.05; **p < 0.01, ***p < 0.001 Ampkα2f/f vs Ampkα2ciKO (same sex); ¤p < 0.05, ¤¤p < 0.01 males vs females (same genotype)Back to article page