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Fig. 6 | Biology of Sex Differences

Fig. 6

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 6

Left ventricular cardiolipin profile in male and female mice 16 weeks after cardiac-specific Ampkα2 deletion. A Total cardiolipin content in male mice. B Total cardiolipin content in female mice. C Relative content of each identified cardiolipin species in male mice. D Relative content of each identified cardiolipin species in female mice. E Expression of genes related to cardiolipin biosynthesis and maturation: acyl-CoA synthetase long-chain family member 1 (Acsl1), CDP-diacylglycerol synthase 1 (Cds1), cardiolipin synthase 1 (Crls1), tafazzin (Taz), elongation of very long chain fatty acids-like 2 (Elovl2), elongation of long chain fatty acids (Elovl5), fatty acid desaturase 1 (Fads1) and fatty acid desaturase 2 (Fads2). ANOVA: µ p < 0.05, µµ p ≤ 0.01 for the sex effect; $p < 0.05, $$p < 0.01 for interaction; Post hoc Tukey test: * p < 0.05; **p < 0.01, ***p < 0.001 Ampkα2f/f vs Ampkα2ciKO (same sex); ¤p < 0.05, ¤¤p < 0.01 males vs females (same genotype)

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