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Fig. 5 | Biology of Sex Differences

Fig. 5

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 5

Cardiomyocyte cytoarchitecture and mitochondrial morphology 16 weeks after cardiac-specific Ampkα2 deletion in male mice. A Transmission electron micrograph of left ventricle of Ampkα2f/f (Aa) and Ampkα2ciKO (Ab-Af) mice. B mRNA expression level of genes encoding mitochondrial dynamics proteins: optic atrophy protein 1 (Opa1), Mitofusin 1 and 2 (Mfn1 and Mfn2) and dynamin-related protein 1 (Drp1). ANOVA: µµ p < 0.01 for the sex effect; $ p < 0.05 for interaction; Post hoc Tukey test: * p < 0.05 Ampkα2f/f vs AmpkciKO (same sex); ¤¤p < 0.01 males vs females (same genotype)

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Biology of Sex Differences

ISSN: 2042-6410

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