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Fig. 2 | Biology of Sex Differences

Fig. 2

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 2

Progression of cardiac function during 16 weeks after cardiac-specific Ampkα2 deletion in male and female mice. Heart weight (A), heart weight-to-body weight ratio (B), and brain natriuretic peptide (Bnp) gene expression (C) in left ventricle after 16 weeks of Ampkα2 deletion. Progression of left ventricular ejection fraction (D), progression of left ventricular fractional shortening (E), progression of left ventricular internal dimension at end-systole (LVIDs) (F) and progression of left ventricular internal dimension at end-diastole (LVIDd) (G) in males. Left ventricular ejection fraction (H), left ventricular fractional shortening (I), left ventricular internal dimension at end-systole (LVIDs) (J) and left ventricular internal dimension at end-diastolic (LVIDd) (K) after 16 weeks of Ampkα2 deletion in females. (n = 5 to 7 per experimental group). ANOVA: §p ≤ 0.05 for the genotype effect; µ p ≤ 0.05 for the sex effect. Post hoc Tukey test: *p < 0.05 Ampkα2f/f vs Ampkα2ciKO (same sex)

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Biology of Sex Differences

ISSN: 2042-6410

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