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Fig. 1 | Biology of Sex Differences

Fig. 1

From: Spatiotemporal AMPKα2 deletion in mice induces cardiac dysfunction, fibrosis and cardiolipin remodeling associated with mitochondrial dysfunction in males only

Fig. 1

Cardiac-specific Ampkα2 inactivation 16 weeks after tamoxifen injection in adult male and female mice. A Protein content of AMPKα2 and AMPKα1 in left ventricle (LV) homogenates. Tubulin is used as a loading control. B Immunoblotting of total AMPK (tAMPK), total ACC (tACC), phosphorylated-AMPK (pAMPK) and phosphorylated-ACC (pACC) in LV. Tubulin is used as a loading control. C Protein content of AMPKα2 and AMPKα1 in skeletal muscle. Actin is used as a loading control. (n = 3 to 4 per experimental group). ANOVA: §p ≤ 0.05, §§p ≤ 0.01, §§§p ≤ 0.001 for the genotype effect. Post hoc Tukey test: *p < 0.05, ***p < 0.001 Ampkα2f/f vs Ampkα2ciKO

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