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Table 2 The effects of sex and CKD on ex vivo heart weights, tibia length, and basal coronary flow

From: Ischemic preconditioning protects the heart against ischemia-reperfusion injury in chronic kidney disease in both males and females

Parameter (unit) Male Female p-value
Sham CKD Sham CKD CKD vs. sham Female vs. male
Body weight (g) 488 ± 8 451 ± 7* 268 ± 4# 254 ± 3*#  < 0.001  < 0.001
Tibia length (cm) 4.27 ± 0.03 4.18 ± 0.06* 3.82 ± 0.04# 3.73 ± 0.03*# 0.049  < 0.001
Heart weight (mg) 2450 ± 68 2541 ± 63 1476 ± 34# 1536 ± 32# 0.210  < 0.001
LV weight (mg) 1319 ± 34 1434 ± 49* 900 ± 33# 1023 ± 34*# 0.005  < 0.001
CF10' (mL/min) 17.5 ± 0.8 17.4 ± 1.0 11.0 ± 0.4# 12.1 ± 0.4# 0.720  < 0.001
Kidney weight (mg) 1330 ± 43 1809 ± 79 989 ± 50# 1189 ± 75 N/A  < 0.001
Lung weight (mg) 1596 ± 55 1765 ± 67 1508 ± 36# 1464 ± 37# 0.242  < 0.001
  1. Values are mean ± SEM, n = 30–55 for body weight, heart weight and CF10’ (sham male: n = 35, CKD male: n = 31, sham female: n = 30, and CKD female: n = 55), and n = 13–19 for tibia length, LV weight, kidney weight and lung weight (sham male: n = 19, CKD male: n = 13, sham female: n = 18, and CKD female: n = 18), *p < 0.05, CKD vs. sham-operated groups, #p < 0.05, females vs. males, respectively, p-values refer to two-way ANOVA (Holm–Sidak post hoc test). CF10' coronary flow collected at the 10th minute or perfusion protocol, CKD chronic kidney disease, LV left ventricular