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Table 1 Summary of methodological variabilities and sex-related effects in previous tDCS studies examining response inhibition

From: Investigating the sex-dependent effects of prefrontal cortex stimulation on response execution and inhibition

Study

Stimulation

Brain Region

n

Males

Sex counterbalanced?

Intensity (mA)

Duration (min)

Online/offline

Task

Study design

Main findings on inhibitory ability

Main findings on sex-related modulation

[83]

Anodal/ Cathodal

SMFC

18

6

No

0.7

9

Offline

SST

Single-blinded, crossover, sham-controlled, pre- and post- tDCS testing

No modulatory effect

Not reported

[40]

Anodal

rPFC

14

3

No

1.5

15

Online

SST

Single-blinded, between-group, sham-controlled

Reduced SSRT

Not reported

[84]

Anodal

rIFC

22

4

No

1.5

18

Online

SST

Single-blinded, crossover, sham-controlled

Reduced SSRT

Not reported

[85]

Anodal

rIFC

13

7

Yes

1.5

20

Online

SST

Single-blinded, crossover, sham-controlled

No modulatory effect

Not reported

[9]

Anodal

rIFG

22

6

Yes

1.5

15

Offline

SST

Between-group, post-tDCS testing

Reduced SSRT

Not reported

[57]

Anodal

lDLPFC

73

36

Yes

1.5

10

Offline

SST

Single-blinded, crossover, sham-controlled pre- and post- tDCS testing

Reduced SSRT

Not reported

[86]

Anodal

OFC

45

16

No

1.5

30

Offline

SST

Single-blinded, between-group, sham-controlled, pre- and post- tDCS testing

No modulatory effect

Not reported

[41]

Anodal

rDLPFC

59

21

Yes

0.5

19

Offline

SST

Single-blinded, between-group, sham-controlled, pre- and post- tDCS testing

Reduced SSRT

Not reported

[87]

Cathodal

rDLPFC

45

12

No

0.5

20

Offline

SST

Single-blinded, between-group, sham-controlled, pre- and post- tDCS testing

Increased SSRT

Not reported

[88]

Anodal

IFC

52

N.S

Yes

1

20

Offline

SST

Between-group, pre- and post- tDCS testing

Reduced SSRT

Not reported

[7]

Anodal

rIFG

11

3

No

1

10

Offline

SST

Crossover, sham-controlled, post-tDCS testing

Reduced SSRT

Not reported

[59]

Anodal

pre-SMA and M1

40

22

No

1

10

Offline

SST

Crossover, sham-controlled, pre- and post- tDCS testing

Reduced SSRT

No effect

[46]

Anodal

DLPFC

73

36

Yes

1.5

10

Offline

SST

Single-blinded, crossover, sham-controlled pre- and post- tDCS testing

Reduced SSRT

Not reported

[89]

Anodal

rIFC

30

14

Yes

1.5

20

Offline

SST

Single-blinded, between-group, sham-controlled, pre- and post- tDCS testing

Reduced SSRT

Not reported

[90]

Anodal/ Cathodal

IFG

72

18

No

1.5

20

Online

SST

Single-blinded, between-group, sham-controlled

No modulatory effect

Not reported

[8]

Anodal/ Cathodal

rIFG

115

29

No

1.5

20

Offline

SST

Single-blinded, between-group, sham-controlled, post-tDCS testing

Reduced SSRT with anodal stimulation

Not reported

  1. r or l before brain region denotes right and left, respectively. Abbreviations: N.S, not specified; SMFC, superior medial frontal cortex; PFC, prefrontal cortex; IFC, inferior frontal cortex; OFC, orbitofrontal cortex; IFG, inferior frontal gyrus; pre-SMA, supplementary motor area; M1, primary motor cortex