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Table 5 Stratified analysis of the association between plasma selenium concentrations (T3, ≥ 94.1 ng/mL vs. T1–2, < 94.1 ng/mL) and incident risk of first total stroke in males

From: Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Subgroups

No. of cases/no. of controls

aAdjusted model

P for interaction

Selenium ≥ 94.1 ng/mL

Selenium < 94.1 ng/mL

OR (95% CI)

Age, years

   

0.288

 < 70

98/110

173/161

0.73 (0.50, 1.08)

 

 ≥ 70

99/135

251/215

0.54 (0.38, 0.76)

 

Body mass index, kg/m2

   

0.067

 < 24

44/89

151/152

0.39 (0.24, 0.63)

 

 ≥ 24

153/156

273/224

0.75 (0.55, 1.02)

 

Current smoking

   

0.739

 No

95/136

233/231

0.72 (0.51, 1.01)

 

 Yes

102/109

191/145

0.54 (0.36, 0.80)

 

Current alcohol drinking

   

0.230

 No

98/106

232/207

0.74 (0.51, 1.06)

 

 Yes

99/139

192/169

0.53 (0.37, 0.77)

 

SBP, mmHg

   

0.759

 < 140

46/92

124/156

0.60 (0.38, 0.96)

 

 ≥ 140

151/153

300/220

0.64 (0.47, 0.88)

 

Glucose, mmol/L

   

0.898

 < 6.1

108/168

274/284

0.66 (0.48, 0.90)

 

 ≥ 6.1 or diabetesb

89/77

150/92

0.66 (0.42, 1.02)

 

TC, mmol/L

   

0.402

 < 5.8

95/107

262/236

0.77 (0.54, 1.10)

 

 ≥ 5.8

102/138

162/140

0.53 (0.36, 0.78)

 

TG, mmol/L

   

0.611

 < 1.2

115/160

246/255

0.71 (0.52, 0.98)

 

 ≥ 1.2

82/85

178/121

0.55 (0.36, 0.84)

 

eGFR, mL/min/1.73 m2

   

0.753

 < 90

64/68

173/141

0.71 (0.45, 1.10)

 

 ≥ 90

133/177

251/235

0.61 (0.45, 0.83)

 

tHcy, μmol/L

   

0.117

 < 12.5

89/105

129/142

0.81 (0.54, 1.22)

 

 ≥ 12.5

108/140

293/234

0.55 (0.39, 0.76)

 

Vitamin E, μg/mL

   

0.007

 < 13.5

117/132

270/277

0.85 (0.62, 1.17)

 

 ≥ 13.5

80/113

154/99

0.39 (0.25, 0.60)

 
  1. Abbreviations: TC, total cholesterol, T tertile, OR odds ratio, CI confidence interval
  2. aORs of first total stroke in relation to serum selenium levels were calculated using multivariate logistic regression models. Each subgroup analysis was adjusted, if not stratified, for age, BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labor intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported diabetes, self-reported atrial fibrillation, and self-reported hyperlipidemia
  3. bDiabetes was defined as a self-reported history of diabetes mellitus, use of anti-diabetic medications, or fasting glucose ≥ 7.0 mmol/L