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Table 5 Stratified analysis of the association between plasma selenium concentrations (T3, ≥ 94.1 ng/mL vs. T1–2, < 94.1 ng/mL) and incident risk of first total stroke in males

From: Sex difference in the association between plasma selenium and first stroke: a community-based nested case-control study

Subgroups No. of cases/no. of controls aAdjusted model P for interaction
Selenium ≥ 94.1 ng/mL Selenium < 94.1 ng/mL OR (95% CI)
Age, years     0.288
 < 70 98/110 173/161 0.73 (0.50, 1.08)  
 ≥ 70 99/135 251/215 0.54 (0.38, 0.76)  
Body mass index, kg/m2     0.067
 < 24 44/89 151/152 0.39 (0.24, 0.63)  
 ≥ 24 153/156 273/224 0.75 (0.55, 1.02)  
Current smoking     0.739
 No 95/136 233/231 0.72 (0.51, 1.01)  
 Yes 102/109 191/145 0.54 (0.36, 0.80)  
Current alcohol drinking     0.230
 No 98/106 232/207 0.74 (0.51, 1.06)  
 Yes 99/139 192/169 0.53 (0.37, 0.77)  
SBP, mmHg     0.759
 < 140 46/92 124/156 0.60 (0.38, 0.96)  
 ≥ 140 151/153 300/220 0.64 (0.47, 0.88)  
Glucose, mmol/L     0.898
 < 6.1 108/168 274/284 0.66 (0.48, 0.90)  
 ≥ 6.1 or diabetesb 89/77 150/92 0.66 (0.42, 1.02)  
TC, mmol/L     0.402
 < 5.8 95/107 262/236 0.77 (0.54, 1.10)  
 ≥ 5.8 102/138 162/140 0.53 (0.36, 0.78)  
TG, mmol/L     0.611
 < 1.2 115/160 246/255 0.71 (0.52, 0.98)  
 ≥ 1.2 82/85 178/121 0.55 (0.36, 0.84)  
eGFR, mL/min/1.73 m2     0.753
 < 90 64/68 173/141 0.71 (0.45, 1.10)  
 ≥ 90 133/177 251/235 0.61 (0.45, 0.83)  
tHcy, μmol/L     0.117
 < 12.5 89/105 129/142 0.81 (0.54, 1.22)  
 ≥ 12.5 108/140 293/234 0.55 (0.39, 0.76)  
Vitamin E, μg/mL     0.007
 < 13.5 117/132 270/277 0.85 (0.62, 1.17)  
 ≥ 13.5 80/113 154/99 0.39 (0.25, 0.60)  
  1. Abbreviations: TC, total cholesterol, T tertile, OR odds ratio, CI confidence interval
  2. aORs of first total stroke in relation to serum selenium levels were calculated using multivariate logistic regression models. Each subgroup analysis was adjusted, if not stratified, for age, BMI, baseline SBP, baseline DBP, smoking status, alcohol consumption, labor intensity, baseline total homocysteine, vitamin E, fasting glucose, estimated glomerular filtration rate (eGFR), anti-platelet drugs, lipoprotein-lowering drugs, glucose-lowering drugs, anti-hypertensive drugs, self-reported hypertension, self-reported diabetes, self-reported atrial fibrillation, and self-reported hyperlipidemia
  3. bDiabetes was defined as a self-reported history of diabetes mellitus, use of anti-diabetic medications, or fasting glucose ≥ 7.0 mmol/L